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Maurice Hugh Frederick
Wilkins CBE FRS (15 December 1916 – 5
October 2004)[3] was
a New Zealand-born British physicist and molecular biologist,
and Nobel laureate whose
research contributed to the scientific understanding of phosphorescence, isotope separation, optical microscopy and X-ray diffraction,
and to the development of radar. He is best known for his
work at King's College London on the structure
of DNA.
Childhood & Early Life
· Wilkins was born in Pongaroa, north Wairarapa, New Zealand where his
father, Edgar Henry Wilkins was a medical doctor. His family had come from
Dublin, where his paternal and maternal grandfathers were, respectively,
Headmaster of Dublin High School and a Chief of Police.
· The Wilkinses moved to Birmingham, England when Maurice was 6.
Later, he attended Wylde Green College and then went to King Edward's School,
Birmingham from
1929 to 1934.
· Wilkins went to St John's College, Cambridge in 1935. He studied
the Natural Sciences Triposspecialising in Physics, and
received a Bachelor
of Arts degree.[when?] Mark
Oliphant who
was one of Wilkins' instructors at St. John's had been appointed to the Chair
of Physics at the University of Birmingham, and had appointed John Randall to his staff. Wilkins
became a Ph.D. student of Randall at the University of Birmingham.
· In 1945, they published four
papers in the Proceedings of the Royal Society on phosphorescence and electron traps.[12][13][14][15] Wilkins received
a PhD for this work in 1940.
Career
· During World
War II Wilkins
developed improved radar screens at Birmingham, then worked on isotope
separation at the Manhattan
Project at
the University of
California, Berkeley during
the years 1944–45.
· Meanwhile, Randall had been
appointed to the Chair of Physics at the University of St Andrews. In 1945, he appointed
Wilkins as Assistant Lecturer in his department at the University of St
Andrews. Randall was negotiating with the Medical Research
Council (MRC)
to set up a laboratory to apply the experimental methods of physics to problems
of biology.
· The combination of these
disciplines as biophysics was a novel idea. The
MRC told Randall that this had to be done in another university. In 1946
Randall was appointed Wheatstone Professor of Physics, in charge of the entire
Physics department at King's College, London, with the funding to set up a
Biophysics Unit. He brought Wilkins with him as Assistant Director of the unit.
They appointed a team of scientists trained in both the physical and biological
sciences.
· King's College received
funding to build completely new Physics and Engineering Departments where
vaults beneath the Strand level College forecourt had been destroyed by bombs
during the War. The Biophysics Unit, several more experimental physics groups
and the theoretical group started to move in, during the early months of 1952.
The laboratories were opened formally by Lord
Cherwell on
27 June. Wilkins' article for Nature described both departments, consistent with his
leadership role and prestige within the college at large.
Major Work
· At King's College, Wilkins
pursued, among other things, X-ray
diffraction work
on ram sperm and DNA that had been obtained from calf thymus by the Swiss
scientist Rudolf
Signer.
The DNA from Signer's lab was much more intact than the DNA which had
previously been isolated. Wilkins discovered that it was possible to produce
thin threads from this concentrated DNA solution that contained highly ordered
arrays of DNA suitable for the production of X-ray diffraction patterns.
· By November 1951, Wilkins
had evidence that DNA in cells as well as purified DNA had a helical structure.[30] Alex Stokes had solved
the basic mathematics of helical diffraction theory and thought that Wilkins's
X-ray diffraction data indicated a helical structure in DNA. Wilkins met with
Watson and Crick and told them about his results. This information from
Wilkins, along with additional information gained by Watson when he heard
Franklin talk about her research during a King's College research meeting,
stimulated Watson and Crick to create their first molecular model of DNA, a
model with the phosphate backbones at the center.
· Early in 1952, Wilkins began
a series of experiments on sepia sperm which were very encouraging.
"I...got much clearer patterns than the previous year.....when I met [Sir William Lawrence] Bragg by chance I showed him
the pattern [which] very clearly offered strong evidence for a helical
structure for DNA....the sharp sperm patterns were very inspiring, and had the
special interest that sperm were real live objects and not just purified DNA
extracted by chemists from living material". Wilkins was particularly
interested in whether living samples would yield meaningful X-ray diffraction
patterns – his results showed they could.
· Following the initial 1953
series of publications on the double helix structure of DNA, Wilkins continued
research as leader of a team that performed a range of meticulous experiments
to establish the helical model as valid among different
biological species, as well as in living systems, to establish the universality
of the double helix structure.[21] He became deputy
director of the MRC Biophysics Unit at King's in 1955, and succeeded Randall as
director of the unit from 1970 to 1972.
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Awards and Honours
·
In
1960 he was presented with the American Public Health
Association's Albert Lasker Award, and in 1962 he was made a
Commander of the Order of the British Empire. Also in 1962 he shared the Nobel Prize in
Physiology or Medicine with
Watson and Crick for the discovery of the structure of DNA.
·
On
Saturday 20 October 1962 the award of Nobel prizes to John
Kendrew and Max
Perutz,
and to Crick, Watson, and Wilkins was satirised in a short sketch in the BBC TV
programme That Was The
Week That Was with
the Nobel Prizes being referred to as 'The Alfred Nobel Peace Pools.
·
In
1969, Wilkins became the founding President of the British Society for Social Responsibility in
Science.
·
In
2000, King's College London opened the Franklin-Wilkins Building in honour of Dr. Franklin's and
Professor Wilkins' work at the college.
Personal Life & Legacy
·
Wilkins
was married twice. His first wife, Ruth, was an art student whom he met whilst
he was at Berkeley. Their marriage ended in divorce, and Ruth bore her son by
Wilkins after their divorce.[41] Wilkins married his
second wife Patricia Ann Chidgey in 1959. They had four children, Sarah,
George, Emily and William. His widow Patricia and the children from their
marriage survive him.
·
In
the years before World War II, he was an active anti-war activist, joining
the Cambridge Scientists
Anti-War Group.
He joined the Communist Party, until the invasion of
Poland by the Soviet Army in September 1939.[42] Formerly classified UK
security service papers reveal that Wilkins came under suspicion of leaking
atomic secrets. The files, released in August 2010, indicate surveillance of
Wilkins ended by 1953.[43] "After the war I
wondered what I would do, as I was very disgusted with the dropping of two
bombs on civilian centres in Japan," he told Britain's Encounterradio program in 1999.
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